منابع مشابه
P89: The Relationship Between the TNFα of the Microglial Cells and the Multiple Sclerosis
TNFα is an inflammatory cytokine and the caspase and apoptotic processes can be activated by TNFα There are two classes of TNFα (solTNF and tmTNFα) which are important from the receptor aspect, so that solTNFα and tmTNFα can attach to the TNFR1, but tmTNFα just attaches to the TNFR2. Microglia cells are resident immune cells of the central nervous ...
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Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...
متن کاملP 113: Effect of Curcumin on Microglial Cells in MS
Multiple sclerosis (MS) is the most common autoimmune disease, especially among young’s. Neuroinflammation results from inflammation in CNS and it may cause different disorders and diseases .It is also known as a detriment in multiple sclerosis. In fact, it causes problems and symptoms in MS. In MS the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal c...
متن کاملThe attenuating effect of curcumin on morphine dependence in rats: the involvement of spinal microglial cells and inflammatory cytokines
Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...
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Background: Neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. Microglial cells, as the first-line defense in the central nervous system, act as a source of neurotoxic factors such as nitric oxide (NO), a free radical which is involved in neuronal cell death. ...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2010
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2960